Overview
Research Associate: Translational Computer Scientist – Strand, London, WC2R 2LS
About Us
The Bioinformatician will join the translational cancer immunology research group led by Professor Sheeba Irshad at King’s College London, supporting a portfolio of integrated translational and clinical research programmes focused on breast cancer biology, tumour immunology, treatment resistance and precision oncology. The post holder will contribute to multiple ongoing translational research initiatives across the Irshad laboratory.
Working closely with clinical, translational and computational collaborators across King’s College London, Guy’s and St Thomas’ NHS Foundation Trust and the Institute of Cancer Research (ICR), the post holder will support integration and analysis of complex clinical and multi-omic datasets generated through translational studies and experimental medicine programmes.
About The Role
A key component of the role will involve development and maintenance of integrated clinical and translational research datasets, linking clinical metadata with high-dimensional molecular profiling platforms including single-cell transcriptomics, spatial transcriptomics, spatial proteomics, flow and mass cytometry, and multiplex imaging datasets.
The role offers an exciting opportunity to work at the interface of cancer immunology, translational oncology and computational biology within a highly collaborative and multidisciplinary research environment.
Key responsibilities of the role are to develop, maintain and analyse integrated clinical and translational research datasets linking anonymised clinical metadata with high-dimensional molecular profiling data.
There will be a requirement to design and implement computational pipelines for analysis of complex multi-omic datasets, with particular emphasis on:
- single-cell and bulk RNA sequencing
- spatial transcriptomics and spatial proteomics
- flow and mass cytometry
- multiplex imaging and related spatial biology platforms
It will be required to Integrate clinical and experimental datasets to support patient stratification, biomarker discovery and investigation of mechanisms underpinning treatment resistance and tumour–immune interactions. Contribute to development and maintenance of reproducible computational workflows and data analysis pipelines across the laboratory.
A key component will be to liaise with bioinformatics collaborators at King’s College London and the Institute of Cancer Research (ICR) to support harmonised analytical approaches and data standards and evaluate and implement emerging computational methods and open-source tools relevant to translational cancer biology and spatial omics.
This is a full time post (35 Hours per week), and you will be offered a fixed term contract until 31/07/2028.
IMPORTANT: Before applying for this role, please make sure you have the right to work in the country where the role is based. Unless it clearly stipulates within in the job advert above that the hiring company is looking to or able to sponsor applicants it is deemed that the hiring employer will only consider applications from those able to comply with and work in the country where the role is based.
